Life span-resolved nanotoxicology identifies nuclear amyloid, altered metabolism and neurodegenerative processes in the nematode Caenorhabditis elegans
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چکیده
منابع مشابه
Age-specific nuclear proteins in the nematode worm Caenorhabditis elegans.
The nematode worm Caenorhabditis elegans is known to undergo characteristic morphological as well as physiological signs of senescence. Two-dimensional gel electrophoresis shows that alterations also occur in the pattern of the nuclear proteins as a function of age. Non-histone proteins whose level exhibits a steep fall with age are egg-specific and not involved in senescence. However, a distin...
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Lifespan is a biological process regulated by several genetic pathways. One strategy to investigate the biology of aging is to study animals that harbor mutations in components of age-regulatory pathways. If these mutations perturb the function of the age-regulatory pathway and therefore alter the lifespan of the entire organism, they provide important mechanistic insights. Another strategy to ...
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ژورنال
عنوان ژورنال: Biopolymers and Cell
سال: 2019
ISSN: 0233-7657,1993-6842
DOI: 10.7124/bc.0009cb